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It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients. It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest. The power reactor information system (pris), developed and maintained by the iaea for over five decades, is a comprehensive database focusing on nuclear power plants worldwide.
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Mechanism of pris high doses of propofol (greater than 3mg/kg/h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism. Propofol infusion syndrome (pris) is a rare and potentially fatal condition that was first reported in children in 1990 Aside from propofol dose, other risk factors for pris include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease.
First identified in the 1990s, pris can be fatal if not recognized and treated promptly.
Propofol infusion syndrome (pris) is defined as an uncommon but potentially fatal condition that can occur in patients receiving prolonged propofol infusions, characterized by severe manifestations such as cardiac failure, rhabdomyolysis, metabolic acidosis, renal failure, and death. Propofol infusion syndrome (pris) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes
